1825-63-4

Basic information

• Product Name: Trimethyl(propoxy)silane
• Synonyms: Propyloxytrimethylsilane;Silane, trimethylpropoxy-;trimethylpropoxy-silan;Trimethylpropoxysilane;trimethylpropoxy-Silane;PROPYL TRIMETHYLSILYL ETHER;PROPOXYTRIMETHYLSILANE;TRIMETHYL-N-PROPOXYSILANE
• CAS NO: 1825-63-4
• Molecular Formula: C₆H₁₆OSi
• Molecular Weight: 132.28
• EINECS: 217-371-1
• Product Categories: Chemical Synthesis;Organometallic Reagents;Organosilicon;Siloxanes
• Mol File: 1825-63-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: <0°C
• Boiling Point: 100-101 °C735 mm Hg(lit.)
• Flash Point: 28 °F
• Appearance: /
• Density: 0.762 g/mL at 25 °C(lit.)
• Vapor Pressure: 40.2mmHg at 25°C
• Refractive Index: n20/D 1.384(lit.)
• BRN: 1732553
• CAS DataBase Reference: Trimethyl(propoxy)silane(CAS DataBase Reference)
• NIST Chemistry Reference: Trimethyl(propoxy)silane(1825-63-4)
• EPA Substance Registry System: Trimethyl(propoxy)silane(1825-63-4)

Safety Data

• Hazard Codes: F
• Statements: 11
• Safety Statements: 16-23-24/25
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• F: 10-21
• TSCA: Yes
• HazardClass: 3.1
• PackingGroup: II
• Hazardous Substances Data: 1825-63-4(Hazardous Substances Data)

Usage

General Description

Trimethyl(propoxy)silane, also known as TMPPOS, is a chemical compound that belongs to the organosilicon family. It is characterized by the presence of both a propoxy group and three methyl groups attached to a silicon atom. Trimethyl(propoxy)silane is commonly used as a reagent in organic synthesis, specifically in metal-catalyzed cross-coupling reactions. TMPPOS serves as a ligand in these reactions, enabling the formation of carbon-carbon and carbon-heteroatom bonds. Its unique chemical structure and reactivity make it a valuable tool in the field of organic chemistry, particularly in the development of new pharmaceuticals and materials. Additionally, it can also be used in the production of specialty chemicals and as a coating agent in the electronics industry.

InChI:InChI=1/C6H16OSi/c1-5-6-7-8(2,3)4/h5-6H2,1-4H3

Upstream product

• 71-23-8 propan-1-ol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 543-67-9 n-propyl nitrite 
• 1825-61-2 Trimethylmethoxysilane 
• 109-94-4 formic acid ethyl ester 
• 5582-62-7 1-trimethylsilyloxy-2-propyne 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 107-31-3 Methyl formate 
• 19108-51-1 trimethyl-trideuteriomethoxy-silane 
• 1529-17-5 phenyltrimethylsilyl ether 
• 18146-00-4 allyloxytrimethylsilane 
• 1825-65-6 butoxytrimethylsilane 
• 1825-62-3 ethyl trimethylsilyl ether 

Downstream Products

• 1825-61-2 Trimethylmethoxysilane 
• 71352-49-3 2-n-propoxycyclohex-2-enone 
• 139332-48-2 Benzoic acid (2R,3R,4S,5R,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-propoxy-tetrahydro-pyran-3-yl ester 
• 7244-77-1 1-nitro-4-propoxybenzene 
• 13040-68-1 n-propyl dichlorophosphite 
• 1912-31-8 propyl methanesulfonate 
• 56859-43-9 C₉H₁₂F₃OP 
• 667-18-5 C₉H₁₂FO₂P 

Relevant articles and documents

Air- And Water-Tolerant (PNP)Ir Precatalyst for the Dehydrogenative Borylation of Terminal Alkynes

This work discloses the facile synthesis and efficacy of (PNP)IrH(OAc), a precatalyst for the dehydrogenative borylation of terminal alkynes (DHBTA). Unlike the previously reported precatalysts in the (PNP)Ir system (PNP = diarylamido/bis(phosphine) pincer), it is air-stable in the solid state. Upon exposure to air in solution, it possesses a useful half-life on the order of 1-100 h, depending on the intensity of mixing. Air-degraded solutions of (PNP)IrH(OAc) retain DHBTA catalytic activity and selectivity upon exposure to the mixture of a terminal alkyne and HBpin. It is also demonstrated that (PNP)Ir-catalyzed DHBTA is compatible with the presence of modest amounts of moisture or air and that the catalyst is sufficiently long-lived to deliver turnover numbers (TONs) of > 100 ?000.

Nanomagnetic zirconia-based sulfonic acid (Fe3O4@ZrO2-Pr-SO3H): A new, efficient and recyclable solid acid catalyst for the protection of alcohols: Via HMDS under solvent free conditions

In the present work, sulfonic acid functionalized nanomagnetic zirconia is prepared by the reaction of (3-mercaptopropyl)trimethoxysilane and nanomagnetic zirconia. Then, nanomagnetic zirconia-based sulfonic acid (Fe3O4@ZrO2/su

Silylation of hydroxy groups with HMDS under microwave irradiation and solvent-free conditions

Phenols and alcohols are silylated with hexamethyldisilazane (HMDS) under microwave irradiation in solvent-free condition in good to excellent yields.