N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Base Information

Chemical Name:N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
CAS No.:217185-07-4
Molecular Formula:C₂₅H₂₆N₄O₂
Molecular Weight:414.507
Hs Code.:

Synonyms:N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Technology Process of N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 3 articles about N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 217185-06-3
N,N'-di(p-nitrobenzoyl)-2,4-dimethyl-2,3,4,5-terahydro-1H-1,5-benzodiazepine

: 217185-07-4
N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 18 - 20 ℃; for 5h; under 15200 - 16720 Torr;
DOI:10.1007/BF02645990

Reference yield:

: 40358-37-0,58414-04-3,119292-64-7
2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 217185-07-4
N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaHCO₃ / CH₂Cl₂ / 5 h / 8 - 10 °C

2: 72 percent / H₂ / Pd/C / ethanol / 5 h / 18 - 20 °C / 15200 - 16720 Torr

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; dichloromethane; 1: Acylation / 2: Hydrogenation;
DOI:10.1007/BF02645990

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 217185-07-4
N,N'-di(p-aminobenzoyl)-2,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaHCO₃ / CH₂Cl₂ / 5 h / 8 - 10 °C

2: 72 percent / H₂ / Pd/C / ethanol / 5 h / 18 - 20 °C / 15200 - 16720 Torr

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; dichloromethane; 1: Acylation / 2: Hydrogenation;
DOI:10.1007/BF02645990