2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

Base Information

Chemical Name:2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine
CAS No.:1428155-04-7
Molecular Formula:C₁₆H₁₇FN₆O
Molecular Weight:328.349
Hs Code.:

2-fluoro-N<sub>1</sub>-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

Synonyms:2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

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Chemical Property of 2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

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Technology Process of 2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

There total 3 articles about 2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1428155-02-5
N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 1428155-04-7
2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1428155-04-7
2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; palladium diacetate; XPhos / water; tert-butyl alcohol / 15 h / 110 °C / Inert atmosphere; Sealed tube

2: ammonium chloride; iron / water; ethanol / 2 h / 90 °C

With palladium diacetate; iron; potassium carbonate; ammonium chloride; XPhos; In ethanol; water; tert-butyl alcohol; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 369-35-7
2-fluoro-4-nitroaniline

: 1428155-04-7
2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; palladium diacetate; XPhos / water; tert-butyl alcohol / 15 h / 110 °C / Inert atmosphere; Sealed tube

2: ammonium chloride; iron / water; ethanol / 2 h / 90 °C

With palladium diacetate; iron; potassium carbonate; ammonium chloride; XPhos; In ethanol; water; tert-butyl alcohol; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2012.06.005