Ethyl 1-methylpiperidine-3-carboxylate

Base Information

Chemical Name:Ethyl 1-methylpiperidine-3-carboxylate
CAS No.:5166-67-6
Molecular Formula:C9H17NO2
Molecular Weight:171.239
Hs Code.:29333990
European Community (EC) Number:225-951-0
NSC Number:64739
DSSTox Substance ID:DTXSID701282086
Nikkaji Number:J236.177I
Wikidata:Q105285327
Mol file:5166-67-6.mol

Synonyms:5166-67-6;Ethyl 1-methylpiperidine-3-carboxylate;Ethyl N-methylpiperidine-3-carboxylate;Ethyl 1-methylnipecotate;Ethyl 1-methyl-3-piperidinecarboxylate;1-METHYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER;1-Methylpiperidine-3-carboxylic acid ethyl ester;EINECS 225-951-0;3-Piperidinecarboxylic acid, 1-methyl-, ethyl ester;MFCD00006496;(S)-ethyl 1-methylpiperidine-3-carboxylate;1-Methyl-3-piperidinecarboxylic Acid Ethyl Ester;NCIOpen2_000180;SCHEMBL153251;VFJJNMLPRDRTCO-UHFFFAOYSA-;(+/-)-Ethyl N-methylnipecotate;DTXSID701282086;1-Methylnipecotic Acid Ethyl Ester;NSC64739;BBL027591;EthylN-methylpiperidine-3-carboxylate;NSC 64739;NSC-64739;STL373429;AKOS000120112;AKOS016344132;PS-5853;SB42961;SB47149;AC-22457;SY018366;A7615;AM20100265;BB 0258864;CS-0000129;E0863;FT-0635568;EN300-18963;Ethyl 1-methyl-3-piperidinecarboxylate, 96%;ETHYL N-METHYL PIPERIDINE-3-CARBOXYLATE;W-105873;Z103734946;Ethyl N-Methyl piperidine-3-carboxylate or Ethyl 1-Methylnipecotate

Suppliers and Price of Ethyl 1-methylpiperidine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl1-Methylpiperidine-3-carboxylate
50mg
$ 45.00

TCI Chemical
Ethyl 1-Methyl-3-piperidinecarboxylate >95.0%(GC)(T)
25g
$ 132.00

TCI Chemical
Ethyl 1-Methyl-3-piperidinecarboxylate >95.0%(GC)(T)
5g
$ 48.00

SynQuest Laboratories
Ethyl 1-methylpiperidine-3-carboxylate 97%
500 mg
$ 16.00

Sigma-Aldrich
Ethyl 1-methyl-3-piperidinecarboxylate 96%
5g
$ 44.60

Frontier Specialty Chemicals
Ethyl1-methylnipecotate
25g
$ 174.00

Frontier Specialty Chemicals
Ethyl1-methylnipecotate
5g
$ 43.00

Chem-Impex
Ethyl1-methyl-3-piperidinecarboxylate,≥95%(GC) ≥95%(GC)
5G
$ 46.22

Chem-Impex
Ethyl1-methyl-3-piperidinecarboxylate,≥95%(GC) ≥95%(GC)
25G
$ 145.60

Chemenu
EthylN-methylpiperidine-3-carboxylate 97%
100g
$ 138.00

Total 88 raw suppliers

Chemical Property of Ethyl 1-methylpiperidine-3-carboxylate

Chemical Property:

Appearance/Colour:Clear colorless to pale yellow liquid
Vapor Pressure:0.186mmHg at 25°C
Refractive Index:n20/D 1.451(lit.)
Boiling Point:211.1 °C at 760 mmHg
PKA:8.56±0.10(Predicted)
Flash Point:68.3 °C
PSA：29.54000
Density:0.997 g/cm³
LogP:0.82920
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:171.125928785
Heavy Atom Count:12
Complexity:159

Purity/Quality:

98% ^*data from raw suppliers

Ethyl1-Methylpiperidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCOC(=O)C1CCCN(C1)C
Uses Reactant for: N-demethylation of tertiary amines Reverse cope elimination reactions Regioselective oxidation Synthesis of chelating agents Sequential Michael-Michael-Dieckmann cyclizations

Technology Process of Ethyl 1-methylpiperidine-3-carboxylate

There total 9 articles about Ethyl 1-methylpiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 122-51-0
orthoformic acid triethyl ester

: 71962-74-8
Ethyl nipecotate

: 5166-67-6
ethyl 1-methylpiperidine-3-carboxylate

Guidance literature:: With platinum on carbon; hydrogen; toluene-4-sulfonic acid; at 120 ℃; for 0.2h; under 30003 Torr; Reagent/catalyst; Inert atmosphere; Autoclave;

Reference yield: 73.0%

: 5166-67-6
ethyl 1-methylpiperidine-3-carboxylate

Guidance literature:

Reference yield: 42.0%

: 71962-74-8
Ethyl nipecotate

JandaJel-REM: JandaJel-REM

: 74-88-4
methyl iodide

: 5166-67-6
ethyl 1-methylpiperidine-3-carboxylate

Guidance literature:: Ethyl nipecotate; JandaJel-REM; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With NCPS-NEt₂; In dichloromethane; at 20 ℃; for 24h; Further stages.;
DOI:10.1021/ol0059403