2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one

Base Information

Chemical Name:2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one
CAS No.:1044871-04-6
Molecular Formula:C₂₄H₂₉N₃O₄
Molecular Weight:423.512
Hs Code.:

Synonyms:2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one

Suppliers and Price of 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one

Chemical Property:

Boiling Point:612.6±65.0 °C(Predicted)
Density:1.25±0.1 g/cm3(Predicted)

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one

There total 6 articles about 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1039310-14-9
3,5-dimethyl-4-(2-pyrrolidin-1-yl-ethoxy)-benzaldehyde

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 1044871-04-6
2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 20 - 155 ℃; for 2h;

Reference yield:

: 21544-81-0
4,6-dimethoxyindoline-2,3-dione

: 1044871-04-6
2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C

1.2: 3 h / 20 °C

1.3: 16 h / 20 °C

2.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 2 h / 155 °C

With dihydrogen peroxide; toluene-4-sulfonic acid; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water;

Reference yield:

: 40891-33-6
3,5-dimethoxyaniline hydrochloride

: 1044871-04-6
2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl ether / 2 h / 170 °C

2.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C

2.2: 3 h / 20 °C

2.3: 16 h / 20 °C

3.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 2 h / 155 °C

With dihydrogen peroxide; toluene-4-sulfonic acid; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide; water;