(5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one

Base Information

Chemical Name:(5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one
CAS No.:176915-12-1
Molecular Formula:C₄₃H₃₇N₃O₁₀
Molecular Weight:755.781
Hs Code.:

(5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one

Synonyms:(5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one

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Chemical Property of (5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one

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Technology Process of (5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one

There total 10 articles about (5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 4-(carbobenzoxyoxy)aniline

: 1026686-21-4
Carbonic acid benzyl ester 2,6-dimethoxy-4-((3aR,4R,10R)-4-methoxy-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-10-yl)-phenyl ester

: 176915-12-1
(5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one

Guidance literature:: With 4 A molecular sieve; boron trifluoride diethyl etherate; In dichloromethane; for 4h;
DOI:10.1021/jm9508806

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 176915-12-1
(5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / TEA / CH₂Cl₂ / 2 h

2: 93 percent / SnCl₂*H₂O / H₂O; ethanol / Heating

3: 23 percent / 4A molecular sieves, BF₃*OEt₂ / CH₂Cl₂ / 4 h

With 4 A molecular sieve; TEA; boron trifluoride diethyl etherate; tin(ll) chloride; In ethanol; dichloromethane; water;
DOI:10.1021/jm9508806

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 176915-12-1
(5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / TEA / CH₂Cl₂ / 2 h

2: 93 percent / SnCl₂*H₂O / H₂O; ethanol / Heating

3: 23 percent / 4A molecular sieves, BF₃*OEt₂ / CH₂Cl₂ / 4 h

With 4 A molecular sieve; TEA; boron trifluoride diethyl etherate; tin(ll) chloride; In ethanol; dichloromethane; water;
DOI:10.1021/jm9508806