4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1427266-35-0
Molecular Formula:C₂₀H₂₅NO₆S
Molecular Weight:407.488
Hs Code.:

Synonyms:4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1427266-30-5
N-(2,2-bis(3,4-dimethoxyphenyl)ethyl)methanesulfonamide

: 1427266-35-0
4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With polyphosphoric acid/silica gel; In toluene; at 100 ℃; for 1h; Reagent/catalyst; Temperature; Microwave irradiation; Green chemistry;
DOI:10.2298/JSC200802076M

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 1427266-35-0
4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: polyphosphoric acid / 0.33 h / 20 °C

2: triethylamine / dichloromethane / 0.67 h / 20 °C

3: silica gel / 1,2-dichloro-ethane / 1 h / 80 °C

With silica gel; triethylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.3390/molecules18021869

Reference yield:

: 87519-61-7
2,2-bis(3,4-dimethoxyphenyl)ethanamine

: 1427266-35-0
4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.67 h / 20 °C

2: silica gel / 1,2-dichloro-ethane / 1 h / 80 °C

With silica gel; triethylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.3390/molecules18021869