Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate

Base Information

Chemical Name:Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate
CAS No.:1252657-76-3
Molecular Formula:C₃₀H₃₉N₃O₅
Molecular Weight:521.657
Hs Code.:

Synonyms:Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate

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Chemical Property of Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate

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Technology Process of Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate

There total 5 articles about Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5781-53-3
monomethyl oxalyl chloride

: 1252655-95-0
1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

: 1252657-76-3
Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1252655-91-6
tert-butyl 4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidine-1-carboxylate

: 1252657-76-3
Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate; methanol / 16 h / 20 °C

2: triethylamine / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 166815-96-9
N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine

: 1252657-76-3
Methyl {4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidin-1-yl}(oxo)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

2: sodium hydroxide / tetrahydrofuran; methanol / 4 h / 70 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

4: hydrogenchloride / ethyl acetate; methanol / 16 h / 20 °C

5: triethylamine / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;