1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

Base Information

Chemical Name:1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine
CAS No.:1252655-95-0
Molecular Formula:C₂₇H₃₇N₃O₂
Molecular Weight:435.61
Hs Code.:

Synonyms:1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

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Chemical Property of 1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

Chemical Property:

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Technology Process of 1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

There total 5 articles about 1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1252655-91-6
tert-butyl 4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidine-1-carboxylate

: 1252655-95-0
1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

Guidance literature:: tert-butyl 4-[(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenoxy)methyl]piperidine-1-carboxylate; With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 16h;

With sodium hydroxide;

Reference yield:

: 912946-93-1
4-(4-methoxycarbonyl-phenoxymethyl)-piperidine-1-carboxylic acid t-butyl ester

: 1252655-95-0
1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran; methanol / 4 h / 70 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

3: hydrogenchloride / ethyl acetate; methanol / 16 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 166815-96-9
N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine

: 1252655-95-0
1-(2-tert-butylphenyl)-4-{[4-(piperidin-4-ylmethoxy)phenyl]carbonyl}piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

2: sodium hydroxide / tetrahydrofuran; methanol / 4 h / 70 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

4: hydrogenchloride / ethyl acetate; methanol / 16 h / 20 °C

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;