Technology Process of (E)-1-bromo-3-(3-iodo-2-methylallyl)-2,5-diisopropoxy-4-methoxybenzene
There total 7 articles about (E)-1-bromo-3-(3-iodo-2-methylallyl)-2,5-diisopropoxy-4-methoxybenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene;
With
zirconocene dichloride; trimethylaluminum;
In
n-heptane; dichloromethane; water;
at -78 - 20 ℃;
for 12h;
Inert atmosphere;
With
iodine;
In
tetrahydrofuran; n-heptane; dichloromethane; water;
at -78 - 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol5011278
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 20 °C / Inert atmosphere
1.2: 3 h / 0 °C / Inert atmosphere
2.1: sodium acetate; acetic acid; bromine / 0.67 h / 20 °C / Inert atmosphere
3.1: sodium tetrahydroborate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
3.2: 0.5 h / Inert atmosphere
4.1: triphenylphosphine; N-chloro-succinimide / dichloromethane / -10 - 0 °C / Inert atmosphere
5.1: dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll) / tetrahydrofuran; hexane / 24 h / 20 °C / Inert atmosphere
6.1: potassium fluoride; water / methanol / 60 h / 45 °C / Inert atmosphere
7.1: zirconocene dichloride; trimethylaluminum / dichloromethane; water; n-heptane / 12 h / -78 - 20 °C / Inert atmosphere
7.2: 1 h / -78 - 0 °C / Inert atmosphere
With
potassium fluoride; sodium tetrahydroborate; N-chloro-succinimide; n-butyllithium; zirconocene dichloride; dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); water; bromine; trimethylaluminum; sodium acetate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; n-heptane; dichloromethane; water;
DOI:10.1021/ol5011278
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine; N-chloro-succinimide / dichloromethane / -10 - 0 °C / Inert atmosphere
2.1: dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll) / tetrahydrofuran; hexane / 24 h / 20 °C / Inert atmosphere
3.1: potassium fluoride; water / methanol / 60 h / 45 °C / Inert atmosphere
4.1: zirconocene dichloride; trimethylaluminum / dichloromethane; water; n-heptane / 12 h / -78 - 20 °C / Inert atmosphere
4.2: 1 h / -78 - 0 °C / Inert atmosphere
With
potassium fluoride; N-chloro-succinimide; zirconocene dichloride; dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); water; trimethylaluminum; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; n-heptane; dichloromethane; water;
DOI:10.1021/ol5011278
