1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene

Base Information

Chemical Name:1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene
CAS No.:1610887-81-4
Molecular Formula:C₁₆H₂₁BrO₃
Molecular Weight:341.245
Hs Code.:

Synonyms:1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene

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Chemical Property of 1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene

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Technology Process of 1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene

There total 6 articles about 1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1610887-80-3
[3-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)prop-1-yne-1-yl]trimethylsilane

: 1610887-81-4
1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene

Guidance literature:: With potassium fluoride; water; In methanol; at 45 ℃; for 60h; Inert atmosphere;
DOI:10.1021/ol5011278

Reference yield:

: 96501-81-4
1,4-diisopropyloxy-2-methoxybenzene

: 1610887-81-4
1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 °C / Inert atmosphere

2.1: sodium acetate; acetic acid; bromine / 0.67 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

4.1: triphenylphosphine; N-chloro-succinimide / dichloromethane / -10 - 0 °C / Inert atmosphere

5.1: dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll) / tetrahydrofuran; hexane / 24 h / 20 °C / Inert atmosphere

6.1: potassium fluoride; water / methanol / 60 h / 45 °C / Inert atmosphere

With potassium fluoride; sodium tetrahydroborate; N-chloro-succinimide; n-butyllithium; dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); water; bromine; sodium acetate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol5011278

Reference yield:

: 1610887-78-9
(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)methanol

: 1610887-81-4
1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; N-chloro-succinimide / dichloromethane / -10 - 0 °C / Inert atmosphere

2: dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll) / tetrahydrofuran; hexane / 24 h / 20 °C / Inert atmosphere

3: potassium fluoride; water / methanol / 60 h / 45 °C / Inert atmosphere

With potassium fluoride; N-chloro-succinimide; dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); water; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol5011278