5-Chloro-2,3-dimethoxybenzeneacetonitrile

Base Information

Chemical Name:5-Chloro-2,3-dimethoxybenzeneacetonitrile
CAS No.:86232-37-3
Molecular Formula:C₁₀H₁₀ClNO₂
Molecular Weight:211.648
Hs Code.:
DSSTox Substance ID:DTXSID901269117

Synonyms:86232-37-3;5-Chloro-2,3-dimethoxybenzeneacetonitrile;DTXSID901269117;2-(5-chloro-2,3-dimethoxyphenyl)acetonitrile;EN300-1979699

Suppliers and Price of 5-Chloro-2,3-dimethoxybenzeneacetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Chloro-2,3-dimethoxybenzeneacetonitrile

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:211.0400063
Heavy Atom Count:14
Complexity:225

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)CC#N)Cl

Technology Process of 5-Chloro-2,3-dimethoxybenzeneacetonitrile

There total 9 articles about 5-Chloro-2,3-dimethoxybenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 143-33-9,25596-52-5
sodium cyanide

: 86232-33-9
5-chloro-1-chloromethyl-2,3-dimethoxybenzene

: 86232-37-3
5-chloro-2,3-dimethoxyphenylacetonitrile

Guidance literature:: In various solvent(s); at 100 ℃; for 2h;

Reference yield: 95.0%

: 143-33-9,25596-52-5
sodium cyanide

: 86232-31-7
1-bromomethyl-5-chloro-2,3-dimethoxybenzene

: 86232-37-3
5-chloro-2,3-dimethoxyphenylacetonitrile

Guidance literature:: In various solvent(s); at 100 ℃; for 2h;

Reference yield:

: 7740-05-8
5-chloro-2-hydroxy-3-methoxy-benzaldehyde

: 86232-37-3
5-chloro-2,3-dimethoxyphenylacetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h

2: 75 percent / K₂CO₃ / acetone / 5 h / Heating

3: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 2) reflux

4: 70 percent / N-bromosuccinimide, azoisobutyronitrile / CCl₄ / 1 h / Heating; Irradiation

5: 95 percent / various solvent(s) / 2 h / 100 °C

With potassium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; hydrazine hydrate; In tetrachloromethane; acetone;