methyl 5-chloro-2,3-dihydroxyphenylacetate

Base Information

• Chemical Name: methyl 5-chloro-2,3-dihydroxyphenylacetate
• CAS No.: 86232-49-7
• Molecular Formula: C₉H₉ClO₄
• Molecular Weight: 216.621
• Mol file: 86232-49-7.mol

Synonyms:methyl 5-chloro-2,3-dihydroxyphenylacetate

Chemical Property of methyl 5-chloro-2,3-dihydroxyphenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-chloro-2,3-dihydroxyphenylacetate

There total 15 articles about methyl 5-chloro-2,3-dihydroxyphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + 5-chloro-2,3-dihydroxyphenylacetic acid (86232-47-5) → methyl 5-chloro-2,3-dihydroxyphenylacetate (86232-49-7)

Guidance literature:

With sulfuric acid; In 1,2-dichloro-ethane;

Reference yield:

5-chloro-2-hydroxy-3-methoxy-benzaldehyde (7740-05-8) → methyl 5-chloro-2,3-dihydroxyphenylacetate (86232-49-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h

2: 75 percent / K₂CO₃ / acetone / 5 h / Heating

3: 77 percent / KMnO₄ / H₂O / 5 h / Heating

4: SOCl₂ / 2 h / Heating

5: diethyl ether / 10 h / 20 °C

6: 45 percent / silver oxide / dioxane; H₂O / 1 h / 95 °C

7: 88 percent / AlBr₃ / benzene / 3 h / Heating

8: 91 percent / conc. H₂SO₄ / 1,2-dichloro-ethane

With potassium hydroxide; potassium permanganate; thionyl chloride; aluminum tri-bromide; sulfuric acid; potassium carbonate; hydrazine hydrate; silver(l) oxide; In 1,4-dioxane; diethyl ether; water; 1,2-dichloro-ethane; acetone; benzene;

Reference yield:

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → methyl 5-chloro-2,3-dihydroxyphenylacetate (86232-49-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 45 percent / chlorine / acetic acid / 5 h / 20 °C

2: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h

3: 75 percent / K₂CO₃ / acetone / 5 h / Heating

4: 77 percent / KMnO₄ / H₂O / 5 h / Heating

5: SOCl₂ / 2 h / Heating

6: diethyl ether / 10 h / 20 °C

7: 45 percent / silver oxide / dioxane; H₂O / 1 h / 95 °C

8: 88 percent / AlBr₃ / benzene / 3 h / Heating

9: 91 percent / conc. H₂SO₄ / 1,2-dichloro-ethane

With potassium hydroxide; potassium permanganate; thionyl chloride; aluminum tri-bromide; sulfuric acid; chlorine; potassium carbonate; hydrazine hydrate; silver(l) oxide; In 1,4-dioxane; diethyl ether; water; acetic acid; 1,2-dichloro-ethane; acetone; benzene;

upstream raw materials:

methanol

5-chloro-2,3-dihydroxyphenylacetic acid

5-chloro-2-hydroxy-3-methoxy-benzaldehyde

5-chloro-2,3-dimethoxybenzaldehyde

Downstream raw materials:

methyl 2,3-diacetoxy-5-chlorophenylacetate