2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone

Base Information

Chemical Name:2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone
CAS No.:503303-80-8
Molecular Formula:C₁₉H₁₉FN₄O₄S
Molecular Weight:418.449
Hs Code.:

Synonyms:2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone

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Chemical Property of 2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone

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Technology Process of 2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone

There total 5 articles about 2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 503177-82-0
2-(methylsulfanyl)pyrimidine-4-carbonyl chloride

: 503303-79-5
1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone

: 503303-80-8
2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone

Guidance literature:: With sodium hydroxide; In dichloromethane; water;
DOI:10.1016/j.bmcl.2004.06.001

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 503303-80-8
2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / NaOH / CH₂Cl₂; H₂O

2.1: O₃ / CH₂Cl₂

2.2: 78 percent / DMS / CH₂Cl₂

3.1: 75 percent / 4-methylbenzenesulfonic acid / toluene / Heating

4.1: 90 percent / H₂ / Pd/C / methanol

5.1: 82 percent / NaOH / CH₂Cl₂; H₂O

With sodium hydroxide; hydrogen; toluene-4-sulfonic acid; ozone; palladium on activated charcoal; In methanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2004.06.001

Reference yield:

: 503072-26-2
2-[2-(4-fluorophenyl)acetyl]-4-oxo-pyrazolidine-1-carboxylic acid benzyl ester

: 503303-80-8
2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / 4-methylbenzenesulfonic acid / toluene / Heating

2: 90 percent / H₂ / Pd/C / methanol

3: 82 percent / NaOH / CH₂Cl₂; H₂O

With sodium hydroxide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2004.06.001