1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone

Base Information

Chemical Name:1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone
CAS No.:503303-79-5
Molecular Formula:C₁₃H₁₅FN₂O₃
Molecular Weight:266.272
Hs Code.:

Synonyms:1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone

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Chemical Property of 1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone

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Technology Process of 1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone

There total 4 articles about 1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 503303-78-4
8-[2-(4-Fluoro-phenyl)-acetyl]-1,4-dioxa-7,8-diaza-spiro[4.4]nonane-7-carboxylic acid benzyl ester

: 503303-79-5
1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2004.06.001

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 503303-79-5
1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / NaOH / CH₂Cl₂; H₂O

2.1: O₃ / CH₂Cl₂

2.2: 78 percent / DMS / CH₂Cl₂

3.1: 75 percent / 4-methylbenzenesulfonic acid / toluene / Heating

4.1: 90 percent / H₂ / Pd/C / methanol

With sodium hydroxide; hydrogen; toluene-4-sulfonic acid; ozone; palladium on activated charcoal; In methanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2004.06.001

Reference yield:

: 503072-26-2
2-[2-(4-fluorophenyl)acetyl]-4-oxo-pyrazolidine-1-carboxylic acid benzyl ester

: 503303-79-5
1-(1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl)-2-(4-fluoro-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 4-methylbenzenesulfonic acid / toluene / Heating

2: 90 percent / H₂ / Pd/C / methanol

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; toluene;
DOI:10.1016/j.bmcl.2004.06.001