({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane

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Chemical Name:({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane
CAS No.:1320344-44-2
Molecular Formula:C₃₃H₆₀O₅Si
Molecular Weight:564.922
Hs Code.:

Synonyms:({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane

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Chemical Property of ({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane

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Technology Process of ({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane

There total 8 articles about ({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1320344-52-2
(2R,3R,6S,7S,8R,9S,10S)-9-(benzyloxy)-11-(methoxymethoxy)-2,6,8,10-tetramethyl-1-[(1,1,1-triisopropylsilyl)oxy]undecan-3,7-diol

: 1320344-44-2
({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0030-1259967

Reference yield:

: 1320344-48-6
(2S,3S,4R,5S,6S)-5-(benzyloxy)-3-[(4-methoxybenzyl)oxy]-7-(methoxymethoxy)-2,4,6-trimethylheptan-1-ol

: 1320344-44-2
({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 0 - 20 °C / Inert atmosphere

2.1: barium hydroxide octahydrate / tetrahydrofuran / 0.5 h / Inert atmosphere

2.2: Inert atmosphere

3.1: borane-dimethyl sulfide complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 1 h / -20 °C / Inert atmosphere

4.1: platinum(IV) oxide; hydrogen / ethyl acetate / 4 h / Inert atmosphere

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1 h / 0 °C / Inert atmosphere

6.1: triphenylphosphine; diethylazodicarboxylate / toluene / 0 - 20 °C / Inert atmosphere

With platinum(IV) oxide; borane-dimethyl sulfide complex; barium hydroxide octahydrate; hydrogen; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; diethylazodicarboxylate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene; 2.1: Horner-Wadsworth-Emmons olefination / 6.1: Mitsunobu reaction;
DOI:10.1055/s-0030-1259967

Reference yield:

: 1204595-67-4
(2S,3S,4S)-3-(benzyloxy)-4-[(4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]-2-methylpentan-1-ol

: 1320344-44-2
({(2R)-2-(2S,5S,6S)-6-[(1S,2S,3S)-2-(benzyloxy)-4-(methoxymethoxy)-1,3-dimethylbutyl]-5-methyltetrahydro-2H-2-pyranylpropyl}oxy)(triisopropyl)silane

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / 1 h / -20 - 0 °C / Inert atmosphere

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 0 - 20 °C / Inert atmosphere

4.1: barium hydroxide octahydrate / tetrahydrofuran / 0.5 h / Inert atmosphere

4.2: Inert atmosphere

5.1: borane-dimethyl sulfide complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 1 h / -20 °C / Inert atmosphere

6.1: platinum(IV) oxide; hydrogen / ethyl acetate / 4 h / Inert atmosphere

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1 h / 0 °C / Inert atmosphere

8.1: triphenylphosphine; diethylazodicarboxylate / toluene / 0 - 20 °C / Inert atmosphere

With platinum(IV) oxide; borane-dimethyl sulfide complex; barium hydroxide octahydrate; hydrogen; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; diethylazodicarboxylate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene; 4.1: Horner-Wadsworth-Emmons olefination / 8.1: Mitsunobu reaction;
DOI:10.1055/s-0030-1259967