N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

Base Information

Chemical Name:N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide
CAS No.:1401076-69-4
Molecular Formula:C₂₃H₂₃N₃O₃
Molecular Weight:389.454
Hs Code.:

Synonyms:N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

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Chemical Property of N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

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Technology Process of N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

There total 3 articles about N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1400984-80-6
N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

: 1401076-69-4
N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In toluene; at 110 ℃; for 20h; Inert atmosphere;

Reference yield:

: 95-55-6
2-amino-phenol

: 1401076-69-4
N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 15 h / 45 °C

2.1: trimethylaluminum / toluene / 0.25 h / 50 °C / Inert atmosphere

2.2: 5 h / 110 °C

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 h / 110 °C / Inert atmosphere

With trimethylaluminum; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; 3.1: Buchwald Coupling;

Reference yield:

: 22244-22-0
ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate

: 1401076-69-4
N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / toluene / 0.25 h / 50 °C / Inert atmosphere

1.2: 5 h / 110 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 h / 110 °C / Inert atmosphere

With trimethylaluminum; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In toluene; 2.1: Buchwald Coupling;