N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

Base Information

• Chemical Name: N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide
• CAS No.: 1400984-80-6
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368
• Mol file: 1400984-80-6.mol

Synonyms:N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

Chemical Property of N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

There total 2 articles about N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.71%

(R)-1-(3-methoxyphenyl)ethylamine (88196-70-7) + ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate (22244-22-0) → N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide (1400984-80-6)

Guidance literature:

(R)-1-(3-methoxyphenyl)ethylamine; With trimethylaluminum; In toluene; at 50 ℃; for 0.25h; Inert atmosphere;

ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate; In toluene; at 110 ℃; for 5h;

With hydrogenchloride; In water; toluene;

Reference yield:

2-amino-phenol (95-55-6) → N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide (1400984-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 15 h / 45 °C

2.1: trimethylaluminum / toluene / 0.25 h / 50 °C / Inert atmosphere

2.2: 5 h / 110 °C

With trimethylaluminum; potassium carbonate; In N,N-dimethyl-formamide; toluene;

Reference yield: 96.77%

N-((R)-1-(3-methoxyphenyl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide (1400984-80-6) + phenyl isocyanate (103-71-9) → N-2-((R)-1-(3-methoxyphenyl)ethyl)-N-4-phenyl-2H-benzo[b][1,4]oxazine-2,4(3H)dicarboxamide (1401076-80-9)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

(R)-1-(3-methoxyphenyl)ethylamine

ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate

2-amino-phenol

Downstream raw materials:

2-((((R)-1-(3-methoxyphenyl)ethyl)amino)methyl)-N-phenyl-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide

N-2-((R)-1-(3-methoxyphenyl)ethyl)-N-4-phenyl-2H-benzo[b][1,4]oxazine-2,4(3H)dicarboxamide

N-((R)-1-(3-methoxyphenyl)ethyl)-4-(pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

(1R)-N-((3,4-dihydro-2H-benzo [b][1,4]oxazin-2-yl)methyl)-1-(3-methoxyphenyl) ethanamine