Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

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Chemical Name:Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester
CAS No.:152932-79-1
Molecular Formula:C₃₉H₄₈ClNO₁₅
Molecular Weight:806.261
Hs Code.:

Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

Synonyms:Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

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Chemical Property of Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

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Technology Process of Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

There total 1 articles about Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 60920-82-3
benzyl 2-acetamido-3-O-allyl-6-O-benzyl-2-deoxy-α-D-glucopyranoside

: Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-fluoro-tetrahydro-pyran-4-yl ester

: 152932-79-1
Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

Guidance literature:: With 4 A molecular sieve; silver perchlorate; tin(ll) chloride; In dichloromethane; at 0 - 25 ℃; for 3h;
DOI:10.1021/ja00072a049

Reference yield:

: 152932-79-1
Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

: C₅₅H₆₅NO₁₈S

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) H₂Ru(PPh₃)4, 2.) p-TsOH / 1.) EtOH, 80 deg C, 1 h, 2.) MeOH, CH₂Cl₂, 25 deg C, 2 h

2: 85 percent / AgClO₄, SnCl₂, 4A molecular sieves / diethyl ether; tetrahydrofuran / 3 h / -15 - 0 °C

3: 90 percent / thiourea, 2,6-lutidine / ethanol; CH₂Cl₂ / 5 h / 65 °C

4: 86 percent / SO₃*NMe₃, pyridine / 24 h / 25 °C

5: NaOMe / methanol / 4 h / 25 °C

With pyridine; 2,6-dimethylpyridine; dihydridotetrakis(triphenylphosphine)ruthenium; trimethyl-sulfo-ammonium betaine; 4 A molecular sieve; sodium methylate; silver perchlorate; toluene-4-sulfonic acid; thiourea; tin(ll) chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00072a049

Reference yield:

: 152932-79-1
Chloro-acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-((2R,3S,4R,5R,6S)-5-acetylamino-4-allyloxy-6-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-4-yl ester

: C₆₁H₇₁NO₁₈

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) H₂Ru(PPh₃)4, 2.) p-TsOH / 1.) EtOH, 80 deg C, 1 h, 2.) MeOH, CH₂Cl₂, 25 deg C, 2 h

2: 85 percent / AgClO₄, SnCl₂, 4A molecular sieves / diethyl ether; tetrahydrofuran / 3 h / -15 - 0 °C

3: 90 percent / thiourea, 2,6-lutidine / ethanol; CH₂Cl₂ / 5 h / 65 °C

With 2,6-dimethylpyridine; dihydridotetrakis(triphenylphosphine)ruthenium; 4 A molecular sieve; silver perchlorate; toluene-4-sulfonic acid; thiourea; tin(ll) chloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00072a049