ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate

Base Information

• Chemical Name: ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate
• CAS No.: 1147869-53-1
• Molecular Formula: C₁₉H₁₈FNO₃
• Molecular Weight: 327.355
• Mol file: 1147869-53-1.mol

Synonyms:ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate

Chemical Property of ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate

There total 1 articles about ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.5%

ethyl 2-diazo-3-hydroxy-3-(4-fluorophenyl)-3-phenylpropanoate (1147869-34-8) → ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate (1147869-53-1) + ethyl (2E)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate (1147869-52-0) + ethyl (2Z)-3-(acetylamino)-2-(4-fluorophenyl)-3-phenylacrylate (1147869-55-3) + ethyl (2E)-3-(acetylamino)-2-(4-fluorophenyl)-3-phenylacrylate (1147869-54-2)

Guidance literature:

With boron trifluoride diethyl etherate; In acetonitrile; at 20 ℃;

DOI:10.1021/jo802775q

Reference yield:

ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate (1147869-53-1) → phenylglyoxylic acid ethyl ester (1603-79-8) + N-acetyl-4-fluorobenzamide (74554-78-2)

Guidance literature:

ethyl (2Z)-3-(acetylamino)-3-(4-fluorophenyl)-2-phenylacrylate; With ozone; In dichloromethane; at 20 ℃; for 2.33333h;

With dimethylsulfide; In dichloromethane;

DOI:10.1021/jo802775q

upstream raw materials:

ethyl 2-diazo-3-hydroxy-3-(4-fluorophenyl)-3-phenylpropanoate

Downstream raw materials:

phenylglyoxylic acid ethyl ester

N-acetyl-4-fluorobenzamide