trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Base Information

Chemical Name:trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine
CAS No.:1451454-05-9
Molecular Formula:C₃₅H₄₃N₃O₇S
Molecular Weight:649.808
Hs Code.:

Synonyms:trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Suppliers and Price of trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

There total 11 articles about trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 56069-39-7
diethyl phenylsulfonylmethylphosphonate

: 1451454-53-7
2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal

: 1451454-05-9
trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Guidance literature:: diethyl phenylsulfonylmethylphosphonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

2S-(2S-benzyloxycarbonylamino-3-phenylpropanamido)-6-(tert-butoxycarbonylamino)hexanal; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c4ob01412j

Reference yield:

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 1451454-05-9
trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / Inert atmosphere

1.2: 24 h / Inert atmosphere

2.1: piperidine / acetonitrile / 0.25 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.2: 24 h / 0 - 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride; potassium hydrogensulfate / tetrahydrofuran; ethyl acetate / 0.58 h / -78 - 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

5.2: 24 h / 0 - 20 °C / Inert atmosphere

With piperidine; potassium hydrogensulfate; lithium aluminium tetrahydride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile; mineral oil; 5.1: |Horner-Wadsworth-Emmons Olefination / 5.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1039/c4ob01412j

Reference yield:

: benzyl 1-{[6-tert-butoxycarbonylamino-1-(methoxy(methyl)amino)-1-oxohexan-2S-yl]amino-1-oxo-3-phenylpropan-2S-yl}carbamate

: 1451454-05-9
trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride; potassium hydrogensulfate / tetrahydrofuran; ethyl acetate / 0.58 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 24 h / 0 - 20 °C / Inert atmosphere

With potassium hydrogensulfate; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; ethyl acetate; mineral oil; 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1039/c4ob01412j