5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine

Base Information

Chemical Name:5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine
CAS No.:1451454-26-4
Molecular Formula:C₃₅H₄₅N₃O₇S
Molecular Weight:651.824
Hs Code.:

Synonyms:5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine

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Chemical Property of 5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine

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Technology Process of 5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine

There total 9 articles about 5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1451454-05-9
trans-5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butyloxycarbonylamine

: 1451454-26-4
5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 26h; under 760.051 Torr;
DOI:10.1021/jm400294w

Reference yield:

: 56069-39-7
diethyl phenylsulfonylmethylphosphonate

: 1451454-26-4
5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 26 h / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; ethanol; mineral oil; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm400294w

Reference yield:

: 108-98-5
thiophenol

: 1451454-26-4
5S-(2'S-benzyloxycarbonylamino-3'phenylpropanamido)-7-(phenylsulfonyl)heptan-1-tert-butyloxycarbonylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

2.1: dihydrogen peroxide; acetic acid / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 16 h / 0 - 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 26 h / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; ethanol; acetone; mineral oil; 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm400294w