(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate
CAS No.:1292309-71-7
Molecular Formula:C₁₇H₂₆N₂O₄
Molecular Weight:322.404
Hs Code.:

Synonyms:(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate

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Chemical Property of (R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate

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Technology Process of (R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate

There total 1 articles about (R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 37553-65-4,64263-83-8,85466-66-6
N-tert-butoxycarbonyl-N-methyl-D-phenylalanine

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1292309-71-7
(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 21h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.01.027

Reference yield: 89.0%

: 1292309-71-7
(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate

: 7103-09-5
4-but-1-enylmagnesium bromide

: 1292309-73-9
C₁₉H₂₇NO₃

Guidance literature:: (R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate; 4-but-1-enylmagnesium bromide; In tetrahydrofuran; at -20 - 0 ℃; for 4.5h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; at -10 ℃; Saturated solution;
DOI:10.1016/j.bmc.2011.01.027

Reference yield:

: 1292309-71-7
(R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl(methyl)carbamate

: 1292308-83-8
C₂₁H₃₅NO

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 4.5 h / -20 - 0 °C / Inert atmosphere

1.2: -10 °C / Saturated solution

2.1: L-Selectride / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 14 h / 20 - 40 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

7.1: copper(l) iodide / tetrahydrofuran; diethyl ether / 12.5 h / -78 - 20 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 2.83 h / 0 - 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; copper(l) iodide; tetrabutyl ammonium fluoride; L-Selectride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2011.01.027