2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

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Chemical Name:2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol
CAS No.:1374004-91-7
Molecular Formula:C₃₈H₃₅NO₆S
Molecular Weight:633.765
Hs Code.:

Synonyms:2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

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Chemical Property of 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

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Technology Process of 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

There total 4 articles about 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1374004-85-9
4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol

: 100-39-0
benzyl bromide

: 1374004-91-7
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 16209-52-2
<4-(benzyloxy)-3-methoxyphenyl>acetaldehyde

: 1374004-91-7
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: propionic acid; phenylboronic acid / toluene / 20 h / Reflux

1.2: 0.5 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With potassium carbonate; propionic acid; phenylboronic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1374004-91-7
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 1 h / Reflux

3.1: propionic acid; phenylboronic acid / toluene / 20 h / Reflux

3.2: 0.5 h / 0 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium tert-butylate; potassium carbonate; propionic acid; phenylboronic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2012.03.026