4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol

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Chemical Name:4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol
CAS No.:1374004-85-9
Molecular Formula:C₃₁H₂₉NO₆S
Molecular Weight:543.64
Hs Code.:

Synonyms:4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol

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Chemical Property of 4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol

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Technology Process of 4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol

There total 2 articles about 4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1374004-85-9
4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 1 h / Reflux

3.1: propionic acid; phenylboronic acid / toluene / 20 h / Reflux

3.2: 0.5 h / 0 °C

With hydrogenchloride; potassium tert-butylate; propionic acid; phenylboronic acid; In tetrahydrofuran; water; toluene;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 210173-72-1
1-benzyloxy-2-methoxy-4-(2-methoxyethenyl)benzene

: 1374004-85-9
4-[2-(4-benzyloxy-3-methoxy-phenyl)-1-hydroxy-ethyl]-1-(toluene-4-sulfonyl)-1H-indol-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / tetrahydrofuran; water / 1 h / Reflux

2.1: propionic acid; phenylboronic acid / toluene / 20 h / Reflux

2.2: 0.5 h / 0 °C

With hydrogenchloride; propionic acid; phenylboronic acid; In tetrahydrofuran; water; toluene;
DOI:10.1016/j.tet.2012.03.026