(2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene

Base Information

Chemical Name:(2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene
CAS No.:102069-89-6
Molecular Formula:C₁₅H₂₃NO₃
Molecular Weight:265.353
Hs Code.:

Synonyms:(2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene

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Chemical Property of (2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene

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Technology Process of (2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene

There total 9 articles about (2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102069-83-0,207511-15-7
2-methoxy-1-<<2(S)-(hydroxymethyl)pyrrolidinyl>carbonyl>benzene

: 102069-89-6
(2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 18 h / Heating

2: 1.) potassiun, tert-butyl alcohol, ammonia, 2.) NH₄Cl / 1.) THF, -78 deg C, 2.) THF, -78 deg C

3: 1.) n-butyllithium / 1.) hexane, THF, -78 deg C, 5 min, 2.) hexane, THF, 30 min, r. t., 3.) hexane, THF, - 78 deg C, 30 min, 4.) hexane, THF, -78 deg C, 30 min

With n-butyllithium; ammonia; potassium; sodium hydride; ammonium chloride; tert-butyl alcohol; In tetrahydrofuran;
DOI:10.1021/ja00231a038

Reference yield:

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 102069-89-6
(2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 4 h / Ambient temperature

2: sodium hydride / tetrahydrofuran / 18 h / Heating

3: 1.) potassiun, tert-butyl alcohol, ammonia, 2.) NH₄Cl / 1.) THF, -78 deg C, 2.) THF, -78 deg C

4: 1.) n-butyllithium / 1.) hexane, THF, -78 deg C, 5 min, 2.) hexane, THF, 30 min, r. t., 3.) hexane, THF, - 78 deg C, 30 min, 4.) hexane, THF, -78 deg C, 30 min

With n-butyllithium; ammonia; potassium; sodium hydride; ammonium chloride; triethylamine; tert-butyl alcohol; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00231a038

Reference yield:

: 102069-84-1
(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]benzene

: 102069-89-6
(2'S,6S)-1-methoxy-6-methyl-6-{[2'-(methoxymethyl)pyrrolidinyl]carbonyl}-1,4-cyclohexadiene

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / K, NH₃ / 2-methyl-propan-2-ol / -78 °C

2: 1.) n-BuLi / 1.) THF, -78 deg C -> 25 deg C, then 0 deg C; 2.) THF, HMPA, -78 deg C

With n-butyllithium; ammonia; In tert-butyl alcohol;
DOI:10.1016/S0040-4039(97)00094-4