methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester

Base Information

Chemical Name:methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester
CAS No.:1188327-68-5
Molecular Formula:C₁₉H₂₀FN₃O₇S
Molecular Weight:453.448
Hs Code.:

Synonyms:methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester

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Chemical Property of methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester

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Technology Process of methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester

There total 4 articles about methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188327-63-0
(S)-N-{3-[3-fluoro-4-(5-hydroxymethyl-pyridin-2-yloxy)phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide

: 124-63-0
methanesulfonyl chloride

: 1188327-68-5
methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1188327-68-5
methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 15 h / 60 °C / Inert atmosphere

2: methanol; sodium tetrahydroborate / 24 h / 20 °C

3: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

Reference yield:

: 790703-59-2
N-[{(5S)-3-(3-fluoro-4-hydroxyphenyl)}-2-oxooxazolidin-5-ylmethyl]acetamide

: 1188327-68-5
methanesulfonic acid (S)-6-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxy}-pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 15 h / 60 °C / Inert atmosphere

2: methanol; sodium tetrahydroborate / 24 h / 20 °C

3: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;