6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Base Information

Chemical Name:6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole
CAS No.:1206800-28-3
Molecular Formula:C₁₈H₁₅BrFN₃O₄
Molecular Weight:436.237
Hs Code.:

Synonyms:6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Suppliers and Price of 6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

There total 7 articles about 6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 369-34-6
3,4-difluoronitrobenzene

: 1206800-27-2
6-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ol

: 1206800-28-3
6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1021/op400317z

Reference yield:

: 31601-41-9
N-(4-methoxy-2-methylphenyl)acetamide

: 1206800-28-3
6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; bromine / 10 h / 8 - 30 °C / Large scale

2.1: hydrogenchloride / methanol; water / Reflux; Large scale

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Large scale

3.2: 1 h / 0 - 5 °C / Large scale

3.3: 25 °C / Inert atmosphere; Large scale

4.1: boron tribromide / dichloromethane

5.1: methanesulfonic acid / tetrahydrofuran

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 70 °C

With hydrogenchloride; methanesulfonic acid; bromine; boron tribromide; sodium hydrogencarbonate; acetic acid; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/op400317z

Reference yield:

: 1206800-17-0
6-bromo-5-methoxy-1H-indazole

: 1206800-28-3
6-bromo-5-(2-fluoro-4-nitrophenoxy)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane

2: methanesulfonic acid / tetrahydrofuran

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 70 °C

With methanesulfonic acid; boron tribromide; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/op400317z