Technology Process of 6-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ol
There total 6 articles about 6-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,4-dihydro-2H-pyran; 6-bromo-1H-indazol-5-ol;
With
methanesulfonic acid;
In
tetrahydrofuran;
at 20 ℃;
for 22h;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
pH=8;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dichloromethane / 3 h / 25 °C / Large scale
2.1: acetic acid; bromine / 10 h / 8 - 30 °C / Large scale
3.1: hydrogenchloride / methanol; water / Reflux; Large scale
4.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Large scale
4.2: 1 h / 0 - 5 °C / Large scale
4.3: 25 °C / Inert atmosphere; Large scale
5.1: boron tribromide / dichloromethane
6.1: methanesulfonic acid / tetrahydrofuran
With
hydrogenchloride; methanesulfonic acid; bromine; boron tribromide; acetic acid; sodium nitrite;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/op400317z
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid; bromine / 10 h / 8 - 30 °C / Large scale
2.1: hydrogenchloride / methanol; water / Reflux; Large scale
3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Large scale
3.2: 1 h / 0 - 5 °C / Large scale
3.3: 25 °C / Inert atmosphere; Large scale
4.1: boron tribromide / dichloromethane
5.1: methanesulfonic acid / tetrahydrofuran
With
hydrogenchloride; methanesulfonic acid; bromine; boron tribromide; acetic acid; sodium nitrite;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/op400317z
