5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione
• CAS No.: 1579296-07-3
• Molecular Formula: C₁₁H₁₁N₃O₃S
• Molecular Weight: 265.293
• Mol file: 1579296-07-3.mol

Synonyms:5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione

Chemical Property of 5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione

There total 4 articles about 5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-bromouracil (51-20-7) + 2-amino-4-methoxybenzenethiol (14482-32-7) → 5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione (1579296-07-3)

Guidance literature:

With sodium carbonate; In diethylene glycol dimethyl ether; water; at 120 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.201303410

Reference yield:

5-bromouracil (51-20-7) + 2-[(2-amino-4-methoxyphenyl)disulfanyl]-4-methoxyaniline (36210-53-4) → 5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione (1579296-07-3)

Guidance literature:

With sodium carbonate; triethylphosphine; In diethylene glycol dimethyl ether; water; at 120 ℃;

DOI:10.1002/chem.201803653

Reference yield:

5-methoxy-2-methylbenzo[d]thiazole (2941-69-7) → 5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione (1579296-07-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 20 h / 100 °C / Inert atmosphere

2: triphenylphosphine / water / 0.5 h / 20 °C / Inert atmosphere

3: sodium carbonate / diethylene glycol dimethyl ether; water / 1 h / 120 °C / Inert atmosphere

With hydrazine hydrate; sodium carbonate; triphenylphosphine; In diethylene glycol dimethyl ether; water;

DOI:10.1002/chem.201303410

upstream raw materials:

2-[(2-amino-4-methoxyphenyl)disulfanyl]-4-methoxyaniline

5-methoxy-2-methylbenzo[d]thiazole

5-bromouracil

2-amino-4-methoxybenzenethiol