ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate

Base Information

• Chemical Name: ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate
• CAS No.: 1454845-32-9
• Molecular Formula: C₂₇H₃₁N₃O₈S
• Molecular Weight: 557.624
• Mol file: 1454845-32-9.mol

Synonyms:ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate

Chemical Property of ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate

There total 3 articles about ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-oxo-5-phenyl-1-phthalimidopentane-2-sulfonyl chloride (1454845-13-6) + glycine ethyl ester hydrochloride (623-33-6) → ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate (1454845-32-9)

Guidance literature:

With triethylamine; In dichloromethane; at 35 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.tet.2013.08.028

Reference yield:

3-phthalimido-1-propene (5428-09-1) → ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate (1454845-32-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dilauryl peroxide / 1,2-dichloro-ethane / Reflux

2: N-chloro-succinimide; hydrogenchloride / water; acetonitrile / 0.25 h / 0 °C

3: triethylamine / dichloromethane / 35 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; N-chloro-succinimide; dilauryl peroxide; triethylamine; In dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1016/j.tet.2013.08.028

Reference yield:

O-ethyl S-4-oxo-4-phenyl-1-phthalimidomethylbutyl dithiocarbonate (226920-42-9) → ethyl N-(5-ethoxycarbonylmethylimino-5-phenyl-1-phthalimidopentane-2-sulfonyl)glycinate (1454845-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide; hydrogenchloride / water; acetonitrile / 0.25 h / 0 °C

2: triethylamine / dichloromethane / 35 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; N-chloro-succinimide; triethylamine; In dichloromethane; water; acetonitrile;

DOI:10.1016/j.tet.2013.08.028

upstream raw materials:

5-oxo-5-phenyl-1-phthalimidopentane-2-sulfonyl chloride

glycine ethyl ester hydrochloride

O-ethyl S-4-oxo-4-phenyl-1-phthalimidomethylbutyl dithiocarbonate

3-phthalimido-1-propene