2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide

Base Information

• Chemical Name: 2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide
• CAS No.: 330943-24-3
• Molecular Formula: C₂₉H₂₆BrN₅O₆S
• Molecular Weight: 652.525

Synonyms:2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide

Chemical Property of 2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide

Chemical Property:

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Technology Process of 2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide

There total 2 articles about 2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) + methyl 2-(4-[(2-t-butylaminosulfonyl)phenyl]phenylcarbonyl)amino-4-nitrobenzoate (358661-72-0) → 2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide (330943-24-3)

Guidance literature:

With trimethylaluminum; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2003.11.079

Reference yield:

4-{2-{[(tert-butyl)amino}sulfonyl}phenyl}benzoic acid (309930-58-3) → 2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide (330943-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 2 h / Heating

2: pyridine / CH₂Cl₂ / 12 h / 20 °C

3: AlMe₃ / CH₂Cl₂ / 12 h / 20 °C

With pyridine; thionyl chloride; trimethylaluminum; In dichloromethane;

DOI:10.1016/j.bmcl.2003.11.079

Reference yield:

2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(5-bromo-pyridin-2-ylcarbamoyl)-5-nitro-phenyl]-amide (330943-24-3) → C29H28BrN5O4S

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate; for 4h; Reflux;

upstream raw materials:

5-bromo-2-pyridylamine

methyl 2-(4-[(2-t-butylaminosulfonyl)phenyl]phenylcarbonyl)amino-4-nitrobenzoate

4-{2-{[(tert-butyl)amino}sulfonyl}phenyl}benzoic acid

Downstream raw materials:

N-(5-bromo-2-pyridinyl)-(2-(4-[(2-aminosulfonyl)phenyl]phenylcarbonyl)amino)-4-nitrophenylcarboxamide

N-(5-bromo-2-pyridinyl)-(2-(4-[(2-aminosulfonyl)phenyl]phenylcarbonyl)amino)-4-methylsulfonylaminophenylcarboxamide

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