2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid

Base Information

Chemical Name:2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid
CAS No.:1609165-61-8
Molecular Formula:C₁₈H₁₄F₂N₂O₃
Molecular Weight:344.318
Hs Code.:

Synonyms:2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid

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Technology Process of 2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid

There total 7 articles about 2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1609165-60-7
ethyl 2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylate

: 1609165-61-8
2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 24922-02-9
Ethyl 3-cyclopropyl-3-oxopropionate

: 1609165-61-8
2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuryl dichloride / dichloromethane / 2 h / 20 °C

2: ethanol / 48 h / Molecular sieve; Reflux

3: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C

With sulfuryl dichloride; water; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 1609165-61-8
2-cyclopropyl-8-[(2,6-difluorobenzyl)oxy]imidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 48 h / Molecular sieve; Reflux

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C

With water; sodium methylate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;