(1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Base Information

• Chemical Name: (1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
• CAS No.: 956485-03-3
• Molecular Formula: C₄₅H₅₁N₃O₈Si
• Molecular Weight: 790.001
• Mol file: 956485-03-3.mol

Synonyms:(1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Chemical Property of (1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

There total 1 articles about (1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C38H47N3O7Si (1160287-32-0) + benzoic acid anhydride (93-97-0) → (1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (956485-03-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jm101207e

Reference yield: 90.0%

(1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (956485-03-3) → (1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane (956485-04-4)

Guidance literature:

With triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1021/jm101207e

upstream raw materials:

C₃₈H₄₇N₃O₇Si

benzoic acid anhydride

Downstream raw materials:

(1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane