ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

Base Information

Chemical Name:ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate
CAS No.:1361005-26-6
Molecular Formula:C₂₆H₁₈F₃NO₆
Molecular Weight:497.427
Hs Code.:

Synonyms:ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

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Chemical Property of ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

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Technology Process of ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

There total 5 articles about ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361005-25-5
ethyl (2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

: 1361005-26-6
ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

Guidance literature:: With selenium(IV) oxide; In 1,4-dioxane; water; at 100 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm201179h

Reference yield:

: 63478-10-4
2-(2'-anilinyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

: 1361005-26-6
ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

2.1: caesium carbonate; acetylacetone / 1-methyl-pyrrolidin-2-one / 48 h / 120 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

4.1: selenium(IV) oxide / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

With selenium(IV) oxide; potassium tert-butylate; caesium carbonate; toluene-4-sulfonic acid; acetylacetone; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; butan-1-ol;
DOI:10.1021/jm201179h

Reference yield:

: 118-48-9
isatoic anhydride

: 1361005-26-6
ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / chlorobenzene / 140 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

3.1: caesium carbonate; acetylacetone / 1-methyl-pyrrolidin-2-one / 48 h / 120 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.2: 0.5 h / Inert atmosphere

5.1: selenium(IV) oxide / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

With selenium(IV) oxide; potassium tert-butylate; caesium carbonate; toluene-4-sulfonic acid; acetylacetone; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; chlorobenzene; butan-1-ol;
DOI:10.1021/jm201179h