4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde

Base Information

Chemical Name:4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde
CAS No.:1361006-09-8
Molecular Formula:C₂₃H₁₄F₃NO₄
Molecular Weight:425.364
Hs Code.:

Synonyms:4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde

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Chemical Property of 4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde

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Technology Process of 4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde

There total 6 articles about 4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1361005-26-6
ethyl (2-formyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl)carbonate

: 1361006-09-8
4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde

Guidance literature:: With potassium hydroxide; In ethanol; water; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm201179h

Reference yield:

: 63478-10-4
2-(2'-anilinyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

: 1361006-09-8
4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

2.1: caesium carbonate; acetylacetone / 1-methyl-pyrrolidin-2-one / 48 h / 120 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

4.1: selenium(IV) oxide / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

5.1: potassium hydroxide / ethanol; water / 1 h / 20 °C / Inert atmosphere

With selenium(IV) oxide; potassium tert-butylate; caesium carbonate; toluene-4-sulfonic acid; acetylacetone; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water; butan-1-ol;
DOI:10.1021/jm201179h

Reference yield:

: 118-48-9
isatoic anhydride

: 1361006-09-8
4-oxo-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,4-dihydroquinoline-2-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc(II) chloride / chlorobenzene / 140 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

3.1: caesium carbonate; acetylacetone / 1-methyl-pyrrolidin-2-one / 48 h / 120 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.2: 0.5 h / Inert atmosphere

5.1: selenium(IV) oxide / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

6.1: potassium hydroxide / ethanol; water / 1 h / 20 °C / Inert atmosphere

With selenium(IV) oxide; potassium tert-butylate; caesium carbonate; toluene-4-sulfonic acid; acetylacetone; potassium hydroxide; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water; chlorobenzene; butan-1-ol;
DOI:10.1021/jm201179h