(2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide

Base Information

Chemical Name:(2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide
CAS No.:1344700-80-6
Molecular Formula:C₃₂H₃₈N₄O₆
Molecular Weight:574.677
Hs Code.:

Synonyms:(2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide

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Chemical Property of (2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide

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Technology Process of (2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide

There total 7 articles about (2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1344700-79-3
4-{2-[(4'-{[(2S)-2-carboxy-1-(methylamino)-1-oxopropan-2-yl](methyl)carbamoyl}biphenyl-4-yl)oxy]ethyl}morpholine

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 1344700-80-6
(2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 16h;

Reference yield:

: 540-38-5
p-Iodophenol

: 1344700-80-6
(2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 17 h / 20 °C / Cooling with ice

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 90 °C

3: potassium carbonate / 1,4-dioxane / 10 h / 90 - 110 °C

4: water; potassium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 - 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 622-40-2
2-(morpholin-4-yl)ethanol

: 1344700-80-6
(2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 17 h / 20 °C / Cooling with ice

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 90 °C

3: potassium carbonate / 1,4-dioxane / 10 h / 90 - 110 °C

4: water; potassium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 - 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;