(1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester

Base Information

• Chemical Name: (1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester
• CAS No.: 898263-09-7
• Molecular Formula: C₃₄H₃₆F₁₇N₃O₆
• Molecular Weight: 905.649
• Mol file: 898263-09-7.mol

Synonyms:(1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester

Chemical Property of (1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester

There total 5 articles about (1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1R,3S,3aR,6aS)-2-(2-Chloro-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester (898263-08-6) + N-butylamine (109-73-9,85404-21-3) → (1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester (898263-09-7)

Guidance literature:

In methanol; at 120 ℃; for 0.166667h; microwave irradiation;

DOI:10.1002/ejoc.200600077

Reference yield:

(S)-2-Amino-propionic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester → (1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester (898263-09-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / Et₃N / dimethylformamide / 0.33 h / 130 °C / microwave irradiation

2: 95 percent / Et₃N / CH₂Cl₂ / 0.5 h / 25 °C

3: 92 percent / methanol / 0.17 h / 120 °C / microwave irradiation

With triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.200600077

Reference yield:

(1R,3S,3aR,6aS)-5-Ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester (898262-98-1) → (1R,3S,3aR,6aS)-2-(2-Butylamino-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester (898263-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 0.5 h / 25 °C

2: 92 percent / methanol / 0.17 h / 120 °C / microwave irradiation

With triethylamine; In methanol; dichloromethane;

DOI:10.1002/ejoc.200600077

upstream raw materials:

(1R,3S,3aR,6aS)-2-(2-Chloro-acetyl)-5-ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester

N-butylamine

(1R,3S,3aR,6aS)-5-Ethyl-3-(4-methoxy-phenyl)-1-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecyl ester

N-Ethylmaleimide