(4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone

Base Information

• Chemical Name: (4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone
• CAS No.: 1027584-88-8
• Molecular Formula: C₂₆H₂₀F₃NO₄
• Molecular Weight: 467.444
• Mol file: 1027584-88-8.mol

Synonyms:(4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone

Chemical Property of (4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone

There total 3 articles about (4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-4'-methoxybenzophenone (103203-53-8) + 4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole (174258-39-0) → (4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone (1027584-88-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 10h;

DOI:10.1021/jm990476x

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → (4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone (1027584-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3: K₂CO₃ / dimethylformamide / 10 h / 65 °C

With hydrogenchloride; potassium carbonate; trichlorophosphate; In chloroform; ethyl acetate; N,N-dimethyl-formamide; 1: Condensation / 2: Chlorination / 3: Alkylation;

DOI:10.1021/jm990476x

Reference yield:

4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide (475480-98-9) → (4-methoxy-phenyl)-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-methanone (1027584-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

2: K₂CO₃ / dimethylformamide / 10 h / 65 °C

With potassium carbonate; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; 1: Chlorination / 2: Alkylation;

DOI:10.1021/jm990476x

upstream raw materials:

3-hydroxy-4'-methoxybenzophenone

4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

4-Trifluoromethylbenzaldehyde

4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide

Downstream raw materials:

(E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic acid ethyl ester

(E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol

C₃₈H₄₁F₃N₂O₈