4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one

Base Information

Chemical Name:4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one
CAS No.:1429874-10-1
Molecular Formula:C₁₄H₁₂F₃N₃O₆S
Molecular Weight:407.327
Hs Code.:

Synonyms:4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one

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Chemical Property of 4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one

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Technology Process of 4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one

There total 6 articles about 4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.3%

: 1429874-17-8
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

: 1429874-10-1
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one

Guidance literature:: With sulfuric acid; nitric acid; at 0 - 50 ℃; for 5.9h;

Reference yield:

: 77541-59-4
5-chloro-4-methoxy-2-methyl-3(2H)-pyridazinone

: 1429874-10-1
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

2: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

3: dihydrogen peroxide; acetic acid / water / 55 °C

4: sulfuric acid; nitric acid / 5.9 h / 0 - 50 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; dihydrogen peroxide; nitric acid; potassium acetate; acetic acid; cesium fluoride; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1429874-10-1
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-nitro-pyridazin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 1 h / 20 °C

2: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

4: dihydrogen peroxide; acetic acid / water / 55 °C

5: sulfuric acid; nitric acid / 5.9 h / 0 - 50 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; dihydrogen peroxide; nitric acid; potassium acetate; acetic acid; cesium fluoride; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water;