[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol

Base Information

Chemical Name:[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol
CAS No.:1223444-57-2
Molecular Formula:C₃₃H₄₁F₂NO₃Si
Molecular Weight:565.776
Hs Code.:

Synonyms:[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol

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Chemical Property of [5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol

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Technology Process of [5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol

There total 6 articles about [5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 914935-67-4
(2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1223444-57-2
[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol

Guidance literature:: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.25h;

Cyclopropanecarboxaldehyde; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;
DOI:10.1021/jm501174m

Reference yield:

: 61079-72-9
2,3,4,-trifluorobenzoic acid

: 1223444-57-2
[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 13.75 h / -78 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran; ethanol / 12 h / 10 °C / Reflux

3.1: 1H-imidazole / dichloromethane / 12.25 h / 20 °C

4.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -78 °C

4.2: 1 h / -78 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; sec.-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane;
DOI:10.1021/jm501174m

Reference yield:

: 914935-65-2
2-((2R,6S)-2,6-dimethylmorpholin-4-yl)-3,4-difluorobenzoic acid

: 1223444-57-2
[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; iodine / tetrahydrofuran; ethanol / 12 h / 10 °C / Reflux

2.1: 1H-imidazole / dichloromethane / 12.25 h / 20 °C

3.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -78 °C

3.2: 1 h / -78 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; sec.-butyllithium; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane;
DOI:10.1021/jm501174m