[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone

Base Information

Chemical Name:[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone
CAS No.:1223444-61-8
Molecular Formula:C₃₃H₃₉F₂NO₃Si
Molecular Weight:563.76
Hs Code.:

Synonyms:[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone

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Chemical Property of [5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone

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Technology Process of [5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone

There total 7 articles about [5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1223444-57-2
[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanol

: 1223444-61-8
[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm501174m

Reference yield:

: 914935-67-4
(2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine

: 1223444-61-8
[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -78 °C

1.2: 1 h / -78 °C

2.1: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C

With sec.-butyllithium; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1021/jm501174m

Reference yield:

: 61079-72-9
2,3,4,-trifluorobenzoic acid

: 1223444-61-8
[5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl]cyclopropylmethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 13.75 h / -78 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran; ethanol / 12 h / 10 °C / Reflux

3.1: 1H-imidazole / dichloromethane / 12.25 h / 20 °C

4.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -78 °C

4.2: 1 h / -78 °C

5.1: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; sec.-butyllithium; pyridinium chlorochromate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane;
DOI:10.1021/jm501174m