(R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile

Base Information

• Chemical Name: (R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile
• CAS No.: 1262413-97-7
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348

Synonyms:(R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile

Chemical Property of (R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile

Chemical Property:

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Technology Process of (R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile

There total 2 articles about (R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethyl-4-hydroxy-5-methyl-benzonitrile (4909-95-9) + 1,2-O-isopropylidene-D-glycerol (14347-78-5,36543-79-0) → (R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile (1262413-97-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; Cooling with ice;

Reference yield:

3-ethyl-4-hydroxy-5-methyl-benzonitrile (4909-95-9) + C13H18O4S → (R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile (1262413-97-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1021/acs.oprd.6b00210

Reference yield:

(R)-4-(2,2-dimethyl-[1,3]dioxolan-4-yl methoxy)-3-ethyl-5-methylbenzonitrile (1262413-97-7) → (R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-N-hydroxy-5-methylbenzylhydrazine (1150644-85-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In methanol; at 60 ℃; for 18h;

upstream raw materials:

3-ethyl-4-hydroxy-5-methyl-benzonitrile

1,2-O-isopropylidene-D-glycerol

Downstream raw materials:

(R)-4-(2,2-dimethyl[1,3]dioxolan-4-ylmethoxy)-3-ethyl-N-hydroxy-5-methyl-benzamidine

4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine

(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol

(R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-N-hydroxy-5-methylbenzylhydrazine

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