2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide

Base Information

Chemical Name:2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide
CAS No.:240418-39-7
Molecular Formula:C₂₂H₂₉ClN₄O₃
Molecular Weight:432.95
Hs Code.:

Synonyms:2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide

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Chemical Property of 2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide

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Technology Process of 2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide

There total 3 articles about 2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 2942-59-8
2-chloronicotinic acid

: 239807-63-7
α-(aminomethyl)-4-[2-(1-methylethoxy)phenyl]-1-piperazineethanol

: 240418-39-7
2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/S0968-0896(00)00151-6

Reference yield:

: 54013-91-1
2-(1-methylethoxy)phenyl-1-piperazine

: 240418-39-7
2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / 1-methyl-pyrrolidin-2-one / 36 h / 100 °C

2: 95 percent / H₂; HCl / Pd/C / methanol; H₂O / 16 h / 20 °C / 2585.74 Torr

3: 44 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / DMAP / CH₂Cl₂ / 20 h / 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; dmap; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; 1: Substitution / 2: Catalytic hydrogenation / 3: Acylation;
DOI:10.1016/S0968-0896(00)00151-6

Reference yield:

: 239807-62-6
α-(azidomethyl)-4-[2-(1-methylethoxy)phenyl]-1-piperazineethanol

: 240418-39-7
2-chloro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂; HCl / Pd/C / methanol; H₂O / 16 h / 20 °C / 2585.74 Torr

2: 44 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / DMAP / CH₂Cl₂ / 20 h / 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; dmap; palladium on activated charcoal; In methanol; dichloromethane; water; 1: Catalytic hydrogenation / 2: Acylation;
DOI:10.1016/S0968-0896(00)00151-6