(1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene

Base Information

Chemical Name:(1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene
CAS No.:181868-46-2
Molecular Formula:C₂₇H₂₄N₆O₅
Molecular Weight:512.525
Hs Code.:

Synonyms:(1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene

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Chemical Property of (1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene

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Technology Process of (1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene

There total 4 articles about (1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 67-56-1
methanol

: 288866-31-9
(1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-phenylsulfonyl(nitro)methyl-cyclopent-2'-ene

: 181868-46-2
(1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene

Guidance literature:: With tetrabutylammonium monopersulfate; sodium carbonate; In dichloromethane;

Reference yield:

: 4157-02-2
cis 2-cyclopentene 1,4-dibenzoate

: 181868-46-2
(1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene

Guidance literature:: Multi-step reaction with 3 steps

1: chiral modular ligand; pempidine / [η³-C3H5PdCl]2 / tetrahydrofuran; dimethylsulfoxide / 20 °C

2: 97 percent / PPh₃; Et₃N / Pd₂dba3*CHCl₃ / tetrahydrofuran / 12 h / 20 °C

3: 71 percent / tetramethylguanidine; tetrabutylammonium oxone; Na₂CO₃ / CH₂Cl₂ / 16 h / 20 °C

With 1,2,2,6,6-pentamethylpiperidine; 1,1,3,3-tetramethylguanidine; Oxone tetrabutylammonium salt; chiral modular ligand; sodium carbonate; triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1: asymmetric allylic alkylation / 2: Alkylation / 3: oxidative esterification;
DOI:10.1021/ja9938837

Reference yield:

: 112233-74-6
N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

: 181868-46-2
(1'R,4'S)-1'-(2-acetamido-6-(N,N-diphenyl)carbamoyloxypurin-9-yl)-4'-methoxycarbonyl-cyclopent-2'-ene

Guidance literature:: Multi-step reaction with 3 steps

1: chiral modular ligand; pempidine / [η³-C3H5PdCl]2 / tetrahydrofuran; dimethylsulfoxide / 20 °C

2: 97 percent / PPh₃; Et₃N / Pd₂dba3*CHCl₃ / tetrahydrofuran / 12 h / 20 °C

3: 71 percent / tetramethylguanidine; tetrabutylammonium oxone; Na₂CO₃ / CH₂Cl₂ / 16 h / 20 °C

With 1,2,2,6,6-pentamethylpiperidine; 1,1,3,3-tetramethylguanidine; Oxone tetrabutylammonium salt; chiral modular ligand; sodium carbonate; triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1: asymmetric allylic alkylation / 2: Alkylation / 3: oxidative esterification;
DOI:10.1021/ja9938837