5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine

Base Information

Chemical Name:5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine
CAS No.:936630-00-1
Molecular Formula:C₂₅H₂₅NO₂S
Molecular Weight:403.545
Hs Code.:

Synonyms:5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine

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Technology Process of 5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine

There total 5 articles about 5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 877614-70-5
3-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-3-carbaldehyde

: 932-31-0
ortho-tolylmagnesium bromide

: 936630-00-1
5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine

Guidance literature:: 3-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-3-carbaldehyde; ortho-tolylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 2h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1016/j.tet.2007.02.055

Reference yield:

: 6-phenyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane

: 936630-00-1
5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trifluoride etherate / 0.25 h / 0 °C

2.1: tetrahydrofuran / 2 h / 20 °C

2.2: 76 percent / boron trifluoride etherate / tetrahydrofuran / 0.25 h / 20 °C

With boron trifluoride diethyl etherate; In tetrahydrofuran; 2.1: Grignard reaction;
DOI:10.1016/j.tet.2007.02.055

Reference yield:

: 83863-40-5
4-phenyl-1-(p-tolylsulfonyl)piperidin-4-ol

: 936630-00-1
5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: m-chloroperoxybenzoic acid / 3 h / 20 °C

2.1: boron trifluoride etherate / 0.25 h / 0 °C

3.1: tetrahydrofuran / 2 h / 20 °C

3.2: 76 percent / boron trifluoride etherate / tetrahydrofuran / 0.25 h / 20 °C

With boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 4.1: Grignard reaction;
DOI:10.1016/j.tet.2007.02.055