877614-70-5

Basic information

• Product Name: 3-Pyrrolidinecarboxaldehyde, 1-[(4-methylphenyl)sulfonyl]-3-phenyl-
• CAS NO: 877614-70-5
• Molecular Formula: C18H19NO3S
• Molecular Weight: 329.42
• Mol File: 877614-70-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-Pyrrolidinecarboxaldehyde, 1-[(4-methylphenyl)sulfonyl]-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinecarboxaldehyde, 1-[(4-methylphenyl)sulfonyl]-3-phenyl-(877614-70-5)
• EPA Substance Registry System: 3-Pyrrolidinecarboxaldehyde, 1-[(4-methylphenyl)sulfonyl]-3-phenyl-(877614-70-5)

Safety Data

• Hazardous Substances Data: 877614-70-5(Hazardous Substances Data)

Upstream product

• 83863-40-5 4-phenyl-1-(p-tolylsulfonyl)piperidin-4-ol 
• 1217795-46-4 C₁₈H₂₁NO₃S 
• 98-59-9 p-toluenesulfonyl chloride 
• 80213-12-3 1-[(4-methylbenzene)-sulfonyl]-4-piperidinol 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 33439-27-9 N-tosyl-4-piperidone 
• 99099-57-7 4-phenyl-1-tosyl-1,2,3,6-tetrahydropyridine 

Downstream Products

• 897625-49-9 4-phenyl-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 
• 936630-34-1 phenyl-[3-phenyl-1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-methanone 
• 936630-03-4 5-(4-methoxyphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine 
• 936629-99-1 1-(4-methylphenylsulfonyl)-4,5-diphenyl-1,2,5,6-tetrahydropyridine 
• 936630-02-3 5-(3-methoxyphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine 
• 936630-33-0 1-(4-methylphenylsulfonyl)-4-phenyl-5-vinyl-1,2,5,6-tetrahydropyridine 
• 936630-00-1 5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine 
• 877614-77-2 3-phenyl-1-p-toluenesulfonyl-1,2,5-trihydropyrrole 

Relevant articles and documents

BF3-promoted synthesis of diarylhexahydrobenzo[f]isoquinoline

Chemical Equation Presented An easy and straightforward synthesis of 6,10b-diarylhexahydrobenzo[f]isoquinoline by the repeated treatment of boron trifluoride etherate (BF3·OEt2) is reported. The overall transformation from 4-arylpiperidin-3-one to benzo[f]isoqulnoline proceeds via ring contraction, chain elongation, and intramolecular electrophilic cyclization in moderate yields. It presents a novel rearrangement reaction catalyzed by boron trifluoride etherate and broadens the scope of application.

New synthesis of 3-arylpyrrolines

We present an easy and straightforward synthesis of 3-arylpyrrolines 4a-g by repeated treatment of 4-aryl-1,2,5,6-tetrahydropyridines 2a-g with m-chloroperoxybenzoic acid (MCPBA) and boron trifluoride etherate (BF 3-OEt2). The transformation proceeds via epoxidation, ring contraction, Baeyer-Villiger oxidation and elimination reaction and affords 3-arylpyrrolines 4a-g with 61-70% yield. This facile strategy was also used to synthesize racemic baclofen (6).