83863-40-5

Usage

Uses

Used in Pharmaceutical Industry:
4-phenyl-1-(p-tolylsulphonyl)piperidin-4-ol is used as a potential drug candidate for various therapeutic applications due to its structural similarity to other piperidine-based drugs. Its unique chemical structure, including the phenyl and p-tolylsulphonyl groups, may contribute to its potential pharmacological properties and therapeutic effects.
Used as a Chemical Intermediate:
4-phenyl-1-(p-tolylsulphonyl)piperidin-4-ol can be used as a chemical intermediate in the synthesis of other compounds, particularly in the development of new pharmaceuticals. Its unique structure and functional groups may be utilized in the design and synthesis of novel drug molecules with improved therapeutic properties.
Note: The specific applications and reasons for using 4-phenyl-1-(p-tolylsulphonyl)piperidin-4-ol in different industries are not provided in the materials. The uses mentioned above are based on the general potential of 4-phenyl-1-(p-tolylsulphonyl)piperidin-4-ol as a pharmaceutical candidate and chemical intermediate. Further research and testing are required to determine its exact applications and benefits in various industries.

InChI:InChI=1/C18H21NO3S/c1-15-7-9-17(10-8-15)23(21,22)19-13-11-18(20,12-14-19)16-5-3-2-4-6-16/h2-10,20H,11-14H2,1H3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 80213-12-3 1-[(4-methylbenzene)-sulfonyl]-4-piperidinol 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 33439-27-9 N-tosyl-4-piperidone 

Downstream Products

• 877614-77-2 3-phenyl-1-p-toluenesulfonyl-1,2,5-trihydropyrrole 
• 83463-16-5 3-ethyl-4-phenylpyridine 
• 936630-01-2 5-(2-methoxyphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine 
• 936630-03-4 5-(4-methoxyphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine 
• 936630-00-1 5-(2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine 
• 936630-02-3 5-(3-methoxyphenyl)-1-(4-methylphenylsulfonyl)-4-phenyl-1,2,5,6-tetrahydropyridine 
• 936630-34-1 phenyl-[3-phenyl-1-(toluene-4-sulfonyl)-pyrrolidin-3-yl]-methanone 
• 936630-33-0 1-(4-methylphenylsulfonyl)-4-phenyl-5-vinyl-1,2,5,6-tetrahydropyridine 
• 877614-70-5 3-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-3-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of cis-3,4-diarylpiperidines and cis-3,4-diaryltetrahydropyrans

Substituted cis-3,4-diarylpiperidines and cis-3,4-diaryltetrahydropyrans are synthesized in modest overall yields starting from 4-aryl-1,2,5,6-tetrahydropyridines and 4-aryl-1,2,5,6-tetrahydropyrans via the following sequence: (1) pinacol-type ring contraction having the?combination of m-chloroperoxybenzoic acid and boron trifluoride etherate, (2) Grignard addition with arylmagnesium bromide reagents and followed by boron trifluoride etherate-mediated intramolecular ring-expanded rearrangement, and (3) hydrogenation with hydrogen on 10% palladium-activated carbon. A facile synthesis of 3,4-diarylpyridines was also described by base-induced aromatization.

New synthesis of 3-arylpyrrolines

We present an easy and straightforward synthesis of 3-arylpyrrolines 4a-g by repeated treatment of 4-aryl-1,2,5,6-tetrahydropyridines 2a-g with m-chloroperoxybenzoic acid (MCPBA) and boron trifluoride etherate (BF 3-OEt2). The transformation proceeds via epoxidation, ring contraction, Baeyer-Villiger oxidation and elimination reaction and affords 3-arylpyrrolines 4a-g with 61-70% yield. This facile strategy was also used to synthesize racemic baclofen (6).