3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid

Base Information

Chemical Name:3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid
CAS No.:943345-24-2
Molecular Formula:C₂₇H₂₁N₃O₄
Molecular Weight:451.481
Hs Code.:

Synonyms:3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid

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Chemical Property of 3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid

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Technology Process of 3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid

There total 5 articles about 3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 943344-71-6
3-{[5-(4-methoxy-phenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid methyl ester

: 943345-24-2
3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid

Guidance literature:: 3-{[5-(4-methoxy-phenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; at 20 - 50 ℃; for 4h;

With hydrogenchloride; In water;

Reference yield:

: 4254-17-5
4-methoxybenzoin

: 943345-24-2
3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Cooling with ice

2.1: acetic anhydride / 0 °C

2.2: 10 - 130 °C

3.1: trichlorophosphate / 1 h / Reflux

3.2: 55 - 75 °C / pH 9

4.1: 1.5 h / 150 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 50 °C

With water; acetic anhydride; diethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 14774-62-0
2-amino-4-(4-methoxyphenyl)-5-phenylfuran-3-carbonitrile

: 943345-24-2
3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride / 0 °C

1.2: 10 - 130 °C

2.1: trichlorophosphate / 1 h / Reflux

2.2: 55 - 75 °C / pH 9

3.1: 1.5 h / 150 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 50 °C

With water; acetic anhydride; sodium hydroxide; trichlorophosphate; In tetrahydrofuran;