4254-17-5

Usage

Uses

4-Methoxybenzoin is used in preparation of Benzofuran-2-one compounds useful for the treatment of cancer.

InChI:InChI=1/C15H14O3/c1-18-13-9-7-12(8-10-13)15(17)14(16)11-5-3-2-4-6-11/h2-10,14,16H,1H3

Upstream product

• 1889-84-5 4'-methoxybenzoin 
• 38828-29-4 α-benzoyloxy-4-methoxy-deoxybenzoin 
• 141-52-6 sodium ethanolate 
• 38828-30-7 4-Methoxybenzoin benzoate 
• 64-17-5 ethanol 
• 151-50-8 potassium cyanide 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-52-7 benzaldehyde 
• 4410-31-5 (RS)-mandelamide 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 67-56-1 methanol 
• 114678-99-8 2-oxo-1,2-diphenylethyl 4-methoxybenzoate 
• 71292-77-8 diethyl α-trimethylsilyloxy-α-(4-methoxybenzoyl)benzylphosphonate 

Downstream Products

• 6910-79-8 α-anilino-4-methoxy-deoxybenzoin 
• 65414-48-4 (+/-)-4-methoxy-benzoin-seqtrans-oxime 
• 66749-56-2 (1RS:2SR)-2-phenyl-1-(4-methoxy-phenyl)-ethanediol-(1,2) 
• 66749-56-2 (1RS:2RS)-2-phenyl-1-(4-methoxy-phenyl)-ethanediol-(1,2) 
• 108791-38-4 2-acetoxy-1-(4-methoxyphenyl)-2-phenylethanone 
• 101274-25-3 4-(4-methoxy-phenyl)-5-phenyl-3H-oxazol-2-one 
• 133296-80-7 3-ethyl-4-(4-methoxy-phenyl)-5-phenyl-3H-oxazole-2-thione 
• 133296-81-8 3-ethyl-5-(4-methoxy-phenyl)-4-phenyl-3H-oxazole-2-thione 
• 21798-21-0 2,5-bis-(4-methoxy-phenyl)-3,6-diphenyl-pyrazine 
• 122803-37-6 1-(4-Methoxy-phenyl)-2-phenyl-naphtho[2,1-b]furan 
• 854651-61-9 2-(4-methoxy-phenyl)-1,3-diphenyl-propane-1,2-diol 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 22711-21-3 4-methoxybenzil 

Relevant academic research and scientific papers

Ultrasonic studies of intermolecular interactions in binary mixtures of 4-methoxy benzoin with various solvents: Excess molar functions of ultrasonic parameters at different concentrations and in different solvents

Density (ρ), ultrasonic velocity (U), for the binary mixtures of 4-methoxy benzoin (4MB) with ethanol, chloroform, acetonitrile, benzene, and di-oxane were measured at 298 K. The solute-solvent interactions and the effect of the polarity of the solvent on

Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement

α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

Visible Light Enabled Formal Cross Silyl Benzoin Reaction as an Access to α-Hydroxyketones

In this work, a visible-light enabled coupling of acylsilanes with aldehydes to give a range of cross-benzoin type products α-hydroxyketones is described. The reaction could proceed at ambient temperature, with the irradiation of low energy visible light, and without addition of photosensitizer or any other additives. (Figure presented.).

UV light-mediated difunctionalization of alkenes through aroyl radical addition/1,4-/1,2-Aryl shift cascade reactions

UV light-mediated difunctionalization of alkenes through an aroyl radical addition/1,4-/1,2-aryl shift has been described. The resulted aroyl radical from a photocleavage reaction added to acrylamide compounds followed by cyclization led to the formation of oxindoles, whereas the addition to cinnamic amides aroused a unique 1,4-aryl shift reaction. Furthermore, the difunctionalization of alkenes of prop-2-en-1-ols was also achieved through aroyl radical addition and a sequential 1,2-aryl shift cascade reaction.

Mechanism of α-ketol-type rearrangement of benzoin derivatives under basic conditions

The mechanism of base-catalyzed rearrangement of ring-substituted benzoins in aqueous methanol was examined by kinetic and product analyses. Substituent effects on the rate and equilibrium constants revealed that the kinetic process has a different electron demand compared to the equilibrium process. Reactions in deuterated solvents showed that the rate of H/D exchange of the α-hydrogen is similar to the overall rate toward the equilibrium state. A proton-inventory experiment using partially deuterated solvents showed a linear dependence of the rate on the deuterium fraction of the solvent, indicating that only one deuterium isotope effect contributes to the overall rate process. All these results point to a mechanism in which the rearrangement is initiated by the rate-determining α-hydrogen abstraction rather than a mechanism with initial hydroxyl hydrogen abstraction as in the general α-ketol rearrangement.

Silicon and silicon oxide surface modification using thiamine-catalyzed benzoin condensations

The benzoin condensation that involves the umpolung coupling of two aldehyde groups has been applied to the formation of functionalized silicon and silicon oxide surfaces using thiamine and other N-heterocyclic carbene (NHC) catalysis in water. This bioorthogonal conjugation of an aldehyde to a modified silicon or silicon oxide surface has been monitored and characterized using X-ray photoelectron spectroscopy and IR spectroscopy. NHC catalysis was found to be efficient in water mediating full conversion of the aldehyde functionalized silicon oxide surfaces at the interface.

An eco-friendly method for synthesis of symmetrical and unsymmetrical benzoin derivatives

A rapid, highly efficient and mild green synthesis of symmetrical and unsymmetrical benzoin derivatives was achieved from the reaction of benzaldehyde derivatives with potassium cyanide in dimethyl sulfoxide under argon gas and ultrasound. This simple method affords benzoin derivatives at room temperature in short reaction times with high yield and purity.

Enantioselective aerobic oxidation of α-hydroxy-ketones catalyzed by oxidovanadium(V) methoxides bearing chiral, N-salicylidene- tert -butylglycinates

Chiral oxidovanadium(V) methoxides prepared from 3,5-disubstituted-N- salicylidene-l-tert-butylglycines and vanadyl sulfate in air-saturated MeOH serve as highly enantioselective catalysts for asymmetric aerobic oxidations and kinetic resolution of alkyl, aryl, and heteroaryl α-hydroxy-ketones with differed α-substituents at ambient temperature in toluene or TBME (tert-butyl methyl ether). The best scenarios involve the use of complexes which bear the tridendate templates derived from 3,5-diphenyl- or 3-o-biphenyl-5-nitro-salicyaldehyde. The kinetic resolution selectivities of the aerobic oxidation process are in the range of 12 to >1000 based on the selectivity factors (krel).

Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof

The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof

The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.